The World Tier you're playing Diablo 4 Gold in directly impacts the level of the loot you can obtain. Bosses in higher World Tiers (such as World Tier 3 and 4) will drop higher-level gear, including Sacred and Ancestral items, which are critical for building top-tier characters in the late game.

Some bosses in Diablo 4 have specific items in their loot tables that you can only obtain from them. These include unique weapons, armor, and legendary aspects tied to specific bosses, making it worthwhile to target specific encounters for the gear you want.

Bosses can drop various rarity types, including Magic, Rare, Legendary, and Unique items. The higher the rarity, the more powerful and customizable the item, with Legendary and Unique items being the most sought-after in the game.

Ashava is one of the World Bosses in Diablo 4, known for her poison-based attacks and massive health pool. She's a formidable enemy, especially at higher World Tiers, but defeating her can yield some excellent rewards. Ashava's loot table includes a mix of Legendary items, Crafting Materials, and Unique gear that are ideal for poison-resistant builds or those looking for high-damage weapons. Notably, Ashava has a higher chance of dropping poison-themed gear, which can be vital for characters who specialize in poison damage or resistance.

As one of the major bosses in Diablo 4's campaign, Astaroth offers a challenging battle with significant rewards. His loot table includes high-damage two-handed weapons, powerful armor pieces, and Legendary aspects that can be applied to specific gear. Astaroth's unique drops often include items that enhance fire-based builds, making him a prime target for players building fire sorcery or melee characters who rely on fire damage.

An iconic boss from Diablo's history, the Butcher returns in cheap D4 materials as a roaming mini-boss that appears at random in dungeons. Despite being a surprise encounter, his loot is far from disappointing. The Butcher has a chance to drop high-level axes, Legendary gear, and even Unique items tied to strength-based characters. His sudden appearances make him both a menace and a boon for those who manage to defeat him.